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Cocaine selectively blocks na+ (sodium) channels, which is the mechanism that leads to

Karen Wright

in Chemistry

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Samantha Barber on April 16, 2018

Cocaine selectively blocks the sodium channels, which is the mechanism that leads to the local anesthetic effects. The voltage-gated sodium channels play very important roles in the body, since they are responsible for action initiation and propagation in excitable cells, such as nerve, muscle and neuroendocrine cells. As other blockers of sodium ion channels, such as lidocaine, Cocaine selectively blocks sodium ion channels that are denied the entry of sodium ions into the cell, which leads to the local anesthetic effects.


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